Yes.
Yes. Zombies were tired out a few years ago and vampires before that. What we need is a good werewolf movie or the mystery unnamed monster.
https://www.wired.com/2016/11/geeks-guide-horror-monsters/
https://www.wired.com/2016/11/geeks-guide-horror-monsters/
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In fact, rather than it being something scooped up by a military research satellite, or accidentally dropped on us via meteorite, make it part of an alien invasion.